HIGH-THROUGHPUT VIRTUAL SCREENING WITH E-PHARMACOPHORE AND MOLECULAR SIMULATIONS STUDY IN THE DESIGNING OF PANCREATIC LIPASE INHIBITORS

High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors

Ganesh Kumar Veeramachaneni, K Kranthi Raj, Leela Madhuri Chalasani, Jayakumar Singh Bondili, Venkateswara Rao Talluri Department of Biotechnology, K L University, Guntur, India Background: Obesity is a progressive metabolic disorder in the current world population, and is characterized by the excess deposition of fat in the adipose tissue.Pancreat

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Insufficient Expression of Cyclooxygenase-2 Protein Is Associated With Retarded Degradation of Aggregated Protein in Diabetic Glomeruli

To elucidate the involvement of cyclooxygenase (COX) in degradation of aggregated protein in diabetic glomeruli, we used streptozotocin (STZ)-induced diabetic mice and aggregated bovine serum albumin (a-BSA) as a model protein.There was a higher deposition of a-BSA in diabetic glomeruli compared to normal glomeruli 18 h after a-BSA injection at 4 a

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Evidence of a Cell Surface Role for Hsp90 Complex Proteins Mediating Neuroblast Migration in the Subventricular Zone

In most mammalian brains, the subventricular zone (SVZ) is a germinative layer that maintains neurogenic activity throughout adulthood.Neuronal precursors arising from this region migrate through the rostral migratory stream (RMS) and reach the olfactory bulbs where they differentiate and integrate into the local circuitry.Recently, studies have sh

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Formation and placement of oil and gas traps within the junction area of Cis-Ural trough and West-Ural outer folding zone

Background.The Cis-Ural trough and its junction area with the West-Ural outer folding zone are known as structures with high oil and gas potential.However, the complexity of the geological structure, due to the wide development of faults of various genesis and morphology, the discrepancy between the structural plans of parts of the sedimentary sect

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